Shop Shiseido Vital Perfection LiftDefine Radiance Serum, 1.4 oz. online at Macys.com. Discover a fresher, more youthful look in 4 weeks.* Experience tightening, lifting and revitalized radiance with an effective face serum. This multi-benefit serum delivers quick lifting, firming and contouring results in a lightweight, non-greasy serum.